| 发明名称 |
Downmodulating an immune response with multivalent antibodies to PD-1 |
| 摘要 |
The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in order to modulate a costimulatory or an inhibitory signal in a immune cell resulting in modulation of the immune response.
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| 申请公布号 |
US6808710(B1) |
申请公布日期 |
2004.10.26 |
| 申请号 |
US20000645069 |
申请日期 |
2000.08.23 |
| 申请人 |
GENETICS INSTITUTE, INC.;DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
WOOD CLIVE;FREEMAN GORDON J. |
| 分类号 |
G01N33/50;A61K38/00;A61K39/00;A61K39/395;A61K45/00;A61K45/06;A61P1/16;A61P3/10;A61P9/00;A61P9/10;A61P15/06;A61P19/02;A61P21/04;A61P25/00;A61P25/28;A61P29/00;A61P31/06;A61P31/12;A61P31/16;A61P31/18;A61P31/20;A61P31/22;A61P33/06;A61P33/12;A61P35/00;A61P37/02;A61P37/04;A61P37/06;A61P37/08;A61P41/00;C07K14/705;C07K16/28;C12N15/09;C12N15/12;C12Q1/02;G01N33/15;G01N33/566;(IPC1-7):A61K39/395 |
主分类号 |
G01N33/50 |
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