BONE TARGETING OF BIODEGRADABLE DRUG-CONTAINING NANOPARTICLES

摘要

This invention provides use of a composition for the manufacture of a medicament for modifying a cellular response in a mammal. The composition to be used an effective amount of biodegradable nanoparticles for administration to a mammal, each of said nanoparticles comprising an active agent, a biodegradable polymer, and a bone targeting agent administering to a mammal an effective amount of a composition comprising a compound absorbed in a biodegradable nanoparticle which is attached to a bone targeting agent. The invention also provides the use of said composition for the manufacture of a medicament for modifying a cellular response in a mammalian cell comprising contacting the mammalian cell with biodegradable nanoparticles. The invention further provides the use of said composition for the manufacture of a medicament for delivering an exogenous substance to a mammal. In addition a composition is disclosed comprising the exogenous substance absorbed into a biodegradable nanoparticle, wherein the biodegradable nanoparticle is covalently attached to a bone targeting agent, and use thereof for the manufacture of a medicament for administration to a mammal. The invention also provides a composition and a process for preparating the composition comprising a biologically active or therapeutic agent of compound, a biodegradable nanoparticle, and a bone targeting agent.