发明名称 |
DIAGNOSTIC AND THERAPEUTIC USE OF STEROIDOGENIC ACUTE REGULATORY PROTEIN FOR NEURODEGENERATIVE DISEASES |
摘要 |
The present invention discloses the differential expression of the steroidogenic acute regulatory protein (StAR) gene in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using the StAR gene and gene products. A method of screening for modulating agents of neurodegenerative diseases is also disclosed. |
申请公布号 |
WO03104811(A3) |
申请公布日期 |
2004.10.14 |
申请号 |
WO2003EP05910 |
申请日期 |
2003.06.05 |
申请人 |
EVOTEC NEUROSCIENCES GMBH;HESTERKAMP, THOMAS;VON DER KAMMER, HEINZ;KRAPPA, RALF;POHLNER, JOHANNES |
发明人 |
HESTERKAMP, THOMAS;VON DER KAMMER, HEINZ;KRAPPA, RALF;POHLNER, JOHANNES |
分类号 |
A01K67/027;A61P25/28;C07K14/47;C07K14/705;C12N15/00;C12N15/09;C12Q1/68;G01N21/78;G01N33/15;G01N33/50;G01N33/53;G01N33/68 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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