发明名称 |
Bicyclic compounds as NR2B receptor antagonists |
摘要 |
This invention provides a compound of the formula (I): wherein R<1 >and R<2 >independently represent a hydrogen atom or the like; X represents a covalent bond or the like: A represents a bicyclic, aromatic, saturated or partially unsaturated heterocyclic or carbocyclic group having from 8 to 12 ring atoms; or the like: B represents a phenyl group or a heteroaryl group having from 5 to 6 ring atoms or the like: These compounds are useful for the treatment of disease conditions caused by overactivation of NMDA NR2B receptor such of pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
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申请公布号 |
US2004204409(A1) |
申请公布日期 |
2004.10.14 |
申请号 |
US20040816700 |
申请日期 |
2004.04.02 |
申请人 |
ANDO KAZUO;KAWAI MAKOTO;KAWAMURA MITSUHIRO;MATSUMIZU MIYAKO;MORITA ASATO;SAKURADA ISAO |
发明人 |
ANDO KAZUO;KAWAI MAKOTO;KAWAMURA MITSUHIRO;MATSUMIZU MIYAKO;MORITA ASATO;SAKURADA ISAO |
分类号 |
A61P25/00;C07D209/08;C07D215/12;C07D215/26;C07D231/56;C07D235/08;C07D235/10;C07D235/12;C07D235/26;C07D239/94;C07D261/20;C07D263/56;C07D471/04;(IPC1-7):A61K31/537;A61K31/495;C07D265/30;C07D211/26 |
主分类号 |
A61P25/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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