CRYSTAL STRUCTURE OF 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1B (PDE1B) AND USES THEREOF

摘要

Crystal structures of phosphodiesterase 1B (PDE1B), and the 3-D atomic coordinates of the PDE1B binding domain, are described and used to obtain PDE1B ligands, including PDE1B inhibitors. The inhibitors are formulated into pharmaceutical compositions and used to treat various psychological disorders.