DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN MAS-RELATED GENE X1 (MRGX1)

摘要

The invention provides a human MrgX1 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, inflammation, respiratory disease, urological disorders and cancer. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, inflammation, respiratory disease, urological disorders and cancer. The invention also features compounds which bind to and/or activate or inhibit the activity of MrgX1 as well as pharmaceutical compositions comprising such compounds.