MICELLAR PREPARATION CONTAINING SPARINGLY WATER-SOLUBLE ANTICANCER AGENT AND NOVEL BLOCK COPOLYMER

摘要

A novel micellar preparation in which the solubility of a sparingly water- soluble anticancer agent has been heightened and which after intravenous administration, enables a high blood concentration to be maintained. The preparation has high medicinal activity and/or is reduced in side effects. T he micellar preparation is formed from a block copolymer represented by the following general formula (1): (1) [wherein R1 represents hydrogen or C1-5 alkyl; R2 represents C1-5 alkylene; R3 represents methylene or ethylene; R4 represents hydrogen or C1-4 acyl; R5 represents hydroxy, optionally substituted aryl(C2-8 alkoxy), substituted C1-4 alkylamino, or amino having a residue of either an amino acid or a peptide derivative; n is an integer of 5 to 1,000; m is an integer of 2 to 300; and x is an integer of 1 to 300; provided that the proportion of hydroxy in the R5's is 0 to 99% and x is not larger than m] and a sparingly water-soluble anticancer agent.