发明名称 |
RECOMBINANT BACTERIAL STRAINS FOR THE PRODUCTION OF NATURAL NUCLEOSIDES AND MODIFIED ANALOGUES THEREOF |
摘要 |
Novel strains of genetically modified prokaryotic micro-organisms capable of expressing polypeptides having the enzyme activity of the enzymes uridine phosphorylase (UdP) and purine nucleoside phosphorylase (PNP) are described; the strains in question can be used, both in the form of whole cells and in the form of crude or purified extracts, to catalyse transglycosylation reactions between a donor nucleoside and an acceptor base with particularly high yields. The associated plasmid vectors are also described. |
申请公布号 |
EP1141328(B1) |
申请公布日期 |
2004.09.29 |
申请号 |
EP19990965565 |
申请日期 |
1999.12.23 |
申请人 |
KERYOS SPA |
发明人 |
BESTETTI, GIUSEPPINA;CALI', SIMONA;GHISOTTI, DANIELA;ORSINI, GAETANO;TONON, GIANCARLO;ZUFFI, GABRIELE |
分类号 |
C12N15/09;C12N1/21;C12N9/10;C12N15/54;C12P19/02;C12P19/38;C12P19/40 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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