发明名称 Method for producing 2-[-5-(4-fluoprophenyl)-3-pyridylmethylaminomethyl]-chromane.
摘要 The present invention relates to a process for the preparation of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, the enantiomers and its salts, characterised in that 5-(4-fluorophenyl)pyridine-3-carbaldehyde is reacted directly with aminomethylchroman or its salts under reducing conditions to give 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, and the latter is, if desired, converted into one of its physiologically acceptable salts by treatment with an acid.
申请公布号 ZA200309164(B) 申请公布日期 2004.09.29
申请号 ZA20030009164 申请日期 2003.11.25
申请人 MERCK PATENT GMBH. 发明人 HEINZ-HERMANN BOKEL;LUDWIG GANTZERT;ELKE SIMON;UDO HELM;STEFFEN NEUENFELD;RALF KNIERIEME;RALD DEVANT;HELMUT REUBOLD
分类号 C07D311/58;C07D405/12 主分类号 C07D311/58
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