POLYNUCLEOTIDE ELICITING ABILITY TO ACCELERATE BIOSYNTHESIS OF PRAVASTATIN PRECURSOR ML-236B (VARIANTS), PLASMID EXPRESSION VECTOR, STRAIN PENICILLIUM CITRINUM (VARIANTS), STRAIN ESCHERICHIA COLI (VARIANTS), POLYPEPTIDE ACCELERATING BIOSYNTHESIS OF ML-236B (VARIANTS), PRAVASTATIN PRECURSOR ML-236B, METHOD FOR PREPARING PRAVASTATIN

摘要

FIELD: biotechnology, biochemistry, microbiology, molecular biology. ^ SUBSTANCE: invention relates to polynucleotides that are able to accelerate biosynthesis of plavastatin precursor ML-236B in microorganisms producing ML-236B after their administration in these microorganisms. These polynucleotides are inserted in vectors that are used for transformation of microorganism-producers of pravastatin precursor that is an inhibitor of enzyme HMG-CoA-redcutase. ^ EFFECT: valuable biochemical properties of polynucleotides. ^ 13 tbl, 6 dwg, 13 ex