BENZENESULFONAMIDE DERIVATIVES AS ANTIPSYCHOTIC AGENTS

摘要

The invention provides compounds of formula (I) wherein A and B represent the groups -(CH₂)_m- and -(CH₂)_n-respectively; R¹ represents hydrogen or C_1-6alkyl; R² represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC_1-6alkyl, trifluoromethyl, trifluoromethoxy, C_1-6alkyl, C_1-6alkoxy, C_1-6alkoxyC_1-6alkyl, C_3-7cycloalkylC_1-6alkoxy, -(CH₂)_pC_3-6cycloalkyl, -(CH₂)_pC_3-6cycloalkyloxy, -COC_1-6alkyl, -SO₂C_1-6alkyl, -SOC_1-6alkyl, -S-C_1-6alkyl, C_1-6alkylsulfonyloxy, C_1-6alkylsulfonylC_1-6alkyl, -CO₂C_1-6alkyl, -CO₂NR⁷R⁸, -SO₂NR⁷R⁸, C_1-6alkylsulfonamido, C_1-6alkylsulfonamidoC_1-6alkyl, -(CH₂)_pNR⁷R⁸, C_1-6alkylamidoC_1-6alkyl, -(CH₂)_pNR⁷COR⁸, arylsulfonyl, arylsulfonyloxy, arylsulfonylC_1-6alkyl, arylsulfonamido, arylcarboxamido, arylsulfonamidoC_1-6alkyl, arylcarboxamidoC_1-6alkyl, aroyl, aroylC_1-6alkyl, arylC_1-6alkanoyl, -SO₂NR⁷R⁸, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl, or a group CONR⁷R⁸ or SO₂NR⁷R⁸ wherein R⁷ and R⁸ together may be fused to form a 5- 7-membered aromatic or non-aromatic heterocyclic ring optionally interrupted by an O or S atom; R³ represents hydrogen or C_1-6alkyl; Ar represents optionally substituted phenyl or optionally substituted monocyclic heteroaryl group; R⁴ represents optionally substituted aryl or optionally substituted heteroaryl; R⁷ and R⁸ each independently represent hydrogen, C_1-6alkyl or together form a 5- to 7-membered heterocyclic ring; Z represents a bond, an oxygen atom or C_1-6alkyl; Y represents hydrogen or C_1-6alkyl; m and n independently represent an integer selected from 1 and 2; p independently represents an integer selected from 0, 1, 2 and 3; q represents an integer from 1 to 3; r represents an integer from 1 to 4; or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful in therapy, in particular as antipsychotic agents.