发明名称 |
INHIBITORS OF FATTY ACID AMIDE HYDROLASE |
摘要 |
Improved competitive inhibitors of FAAH employ an alpha-keto heterocyclic pharmacophore and a binding subunit having a <-unsaturation. The alpha-keto heterocyclic pharmacophore and a binding subunit are attached to one another, preferably by a hydrocarbon chain. The improvement lies in the use of a heterocyclic pharmacophore selected from oxazoles, oxadiazoles, thiazoles, and thiadiazoles that have alkyl or aryl substituents at their 4 and/or 5 positions. The improved competitive inhibitors of FAAH display enhanced activity over conventional competitive inhibitors of FAAH. |
申请公布号 |
WO2004033652(A3) |
申请公布日期 |
2004.09.16 |
申请号 |
WO2003US31975 |
申请日期 |
2003.10.08 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE;BOGER, DALE, L. |
发明人 |
BOGER, DALE, L. |
分类号 |
A61P25/00;C07D263/32;C07D263/34;C07D263/56;C07D271/10;C07D277/24;C07D277/64;C07D285/12;C07D413/04;C07D413/14;C07D417/14;C07D498/04 |
主分类号 |
A61P25/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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