TRICYCLIC RING COMPOUND, METHOD FOR PRODUCING THE SAME AND USE OF THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a compound exhibiting an excellent CCR5 antagonistic effect, and useful as a preventing and treating agent of HIV infection to human peripheral blood monocyte cells, and especially of AIDS. SOLUTION: This compound or its salt is expressed by the formula [wherein, R1is a 5- or 6-membered ring; Z1is a 5- or 6-membered aromatic ring; Z2is a group expressed by Z2aW2Z2bäwherein, Z2a, Z2bare each O, S(O)q(wherein, (q) is 0, 1 or 2), imino or a bonding; and W2is an alkylene chain}; and W is a group expressed by the formulae äwherein, X is CH or N; (n), (n') are each 0 or 1 to 4 integer; (m), (m') are each 1 or 2; Y is a group expressed by O, S(O)p(wherein, (p) is 0, 1 or 2), CH2or NR4(wherein, R4is H, a lower alkyl or a lower acyl); and R2is a nitrogen-containing heterocyclic group or the like}]. COPYRIGHT: (C)2004,JPO&NCIPI