发明名称 Certain 1,3-disubstituted isoquinoline derivatives
摘要 Condensed pyridine compounds represented by formula (I):wherein: R<1 >and R<3 >are, independently, hydrogen, halogen, lower alkyl, or lower alkoxy; R<2 >represents an amino substituent; ring A is a benzene ring, pyridine ring, thiophene ring, or furan ring; and B represents a substituent containing a ring structure. Also, pharmaceutically acceptable salt and hydrates thereof. These compounds are clinically useful medicaments having; serotonin antagonism, and in particular, for treating, ameliorating, or preventing spastic paralysis. They are also useful as central muscle relaxants for ameliorating myotonia.
申请公布号 US6790844(B2) 申请公布日期 2004.09.14
申请号 US20010852850 申请日期 2001.05.11
申请人 EISAI CO., LTD 发明人 UENO KOHSHI;SASAKI ATSUSHI;KAWANO KOKI;OKABE TADASHI;KITAZAWA NORITAKA;TAKAHASHI KEIKO;YAMAMOTO NOBORU;SUZUKI YUICHI;MATSUNAGA MANABU;KUBOTA ATSUHIKO
分类号 C07D217/22;C07D217/24;C07D401/04;C07D401/06;C07D401/10;C07D401/12;C07D405/04;C07D405/10;C07D409/04;C07D409/14;C07D413/10;C07D417/04;C07D417/12;C07D471/04;C07D491/04;C07D491/10;C07D495/04;(IPC1-7):A61K31/33;A61K31/47;A61K31/495;C07D241/04;C07D217/00 主分类号 C07D217/22
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