VERFAHREN ZUR BESTIMMUNG DER ABSOLUTEN KONFIGURATION VON CHIRALEN VERBINDUNGEN

摘要

The object of the present invention is to provide a novel general-purpose method of precisely and easily determining the absolute configuration of chiral compounds having a wide variety of basic groups. The present invention provides a method for determining the absolute configuration of a chiral compound which comprises: coordinating the chiral compound to a metalloporphyrin, the metalloporphyrin having a carbon chain-crosslinked porphyrin dimer structure in which one of the two porphyrin rings has at least one ethyl or substituent bulkier than ethyl at at least one of the second peripheral carbon atoms from the carbon atom at the carbon chain crosslink site, the chiral compound having an asymmetric carbon bonded to a basic group capable of coordinating to the metal of the other porphyrin ring of the metalloporphyrin dimer or an asymmetric carbon atom adjacent to the carbon atom bonded to the basic group; and analyzing the resultant coordination compound by circular dichroism spectrophotometry to determine the absolute configuration of the asymmetric carbon of the chiral compound based on the sign of the Cotton effect.