| 发明名称 |
Compositions and methods for modulating lymphocyte activity |
| 摘要 |
The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.
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| 申请公布号 |
US2004175380(A1) |
申请公布日期 |
2004.09.09 |
| 申请号 |
US20030600997 |
申请日期 |
2003.06.20 |
| 申请人 |
ALLISON JAMES P.;MURPHY KENNETH P.;WATANABE NORIHIKO;MURPHY THERESA L.;YANG JIANFEI;ZANG XINGXING |
发明人 |
ALLISON JAMES P.;MURPHY KENNETH P.;WATANABE NORIHIKO;MURPHY THERESA L.;YANG JIANFEI;ZANG XINGXING |
| 分类号 |
C07K14/705;C12N15/12;(IPC1-7):A61K39/395 |
主分类号 |
C07K14/705 |
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