发明名称 |
Methods and compositions for treatment of inflammatory disease using cadherin-11 modulating agents |
摘要 |
A method for treating inflammatory joint diseases by inhibiting cadherin-11 mediated cellular function using a cadherin-11 modulating agent is provided. Also provided are screening assays for identifying pharmaceutical lead compounds capable of modulating cellular functions of cadherin-11 such as cell proliferation, apoptosis, factor secretion, and binding of cadherin-11 to cadherin-11 counter-receptor inhibiting binding of cadherin-11 to its counter-receptor either in the context of a cell or in soluble form.
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申请公布号 |
US6787136(B1) |
申请公布日期 |
2004.09.07 |
申请号 |
US20000654328 |
申请日期 |
2000.09.01 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
BRENNER MICHAEL B.;VALENCIA XAVIER |
分类号 |
A61K38/00;C07K14/705;C07K16/28;(IPC1-7):A61K39/395 |
主分类号 |
A61K38/00 |
代理机构 |
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地址 |
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