发明名称 BENZOXAZEPINONES AND THEIR USE AS SQUALENE SYNTHASE INHIBITORS
摘要 There is disclosed a compound represented by the formula [I]: wherein R1 is optionally substituted 1-carboxyethyl group, optionally substituted alkyl-sulfonyl group, optionally substituted (carboxy-cycloalkyl)-alkyl group, -X1-X2-Ar-X3-X4-COOH (wherein X1 and X4 are a bond or alkylene group, X2 and X3 are a bond, -O-, -S-, Ar is divalent aromatic group etc.), R2 is alkyl group optionally substituted with alkanoyloxy group and/or hydroxy group, R3 is alkyl group, and W is halogen atom, etc., or a salt thereof. The compound has the cholesterol lowering activity and the triglyceride lowering activity and is useful for preventing and/or treating hyperlipidemia.
申请公布号 PL360243(A1) 申请公布日期 2004.09.06
申请号 PL20010360243 申请日期 2001.06.22
申请人 TAKEDA CHEMICAL INDUSTRIES LTD 发明人 KORI MASAKUNI;MIKI TAKASHI;NISHIMOTO TOMOYUKI;TOZAWA RYUICHI
分类号 A61P3/06;C07D267/14;C07D413/12;C07D417/12 主分类号 A61P3/06
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