DERMOPHARMACEUTICALLY AND COSMETICALLY ACTIVE OLIGOPEPTIDES

摘要

The invention relates to oligopeptides and derivatives thereof, to peptide analogs and derivatives thereof and to pharmaceutically acceptable salts of the compounds, which correspond to general formula (I), wherein: R<1> represents H, -C(O)-R<7>, -SO2-R<7>, -C(O)-OR<7> or -C(O)-N(R<7>)2; R<2> represents, independent of one another, H or -(C1-C4) alkyl; R<3> and R<6> represent, independent of one another, -(CH2)q-N(R<1>)R<8>; R<4> and R<5> represent, independent of one another, CH2-OR<2>, -CH(CH3)OR<8> or CH2-CH2-OR<8>; R<7> represents hydrogen, optionally substituted (C1-C19) alkyl, optionally substituted C1-C19 alkenyl, phenyl-C1-C4 alkyl whose phenyl radical is optionally substituted with amino in the p position; R<8> represents H, -(C1-C4) alkyl, -C(O)-R<7>, -C(O)-OR<7>, -C(O)-N(R<7>)2 or -SO2-R<7>; X represents oxygen (-O-) or -NH- or; XR<7>, with X = O, also represents the esters of alpha -tocopherol, tocotrienol or retinol or the carboxylic acid (with R<7> = H); m, n, p represent, independent of one another, zero or 1, and; q in R<3> and in R<6> represents, independent of one another, an integer from 1 to 4, with the provision that the following conditions do not simultaneously occur: R<4> = -CH (CH3) -OH and R<5> = -CH (CH3) -OH and R<6> = -(CH2)4-NH2. The invention also relates to dermopharmaceutically and cosmetically active compositions containing at least one compound of formula (I).