发明名称 |
Oligomeric compounds having modified bases for binding to cytosine and uracil or thymine and their use in gene modulation |
摘要 |
Oligomer compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capble of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers has a modified base for binding to a cytosine, uracil, or thymine base in the opposite strand. Oligonucleotide/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein the oligomer has a modified base for binding to a cytosine, uracil, or thymine base in the opposite strand.
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申请公布号 |
US2004171030(A1) |
申请公布日期 |
2004.09.02 |
申请号 |
US20030700920 |
申请日期 |
2003.11.04 |
申请人 |
BAKER BRENDA F.;ELDRUP ANNE B.;MANOHARAN MUTHIAH;BHAT BALKRISHEN;GRIFFEY RICHARD;SWAYZE ERIC E.;CROOKE STANLEY T.;RAJEEV KALLANTHOTTATHIL G. |
发明人 |
BAKER BRENDA F.;ELDRUP ANNE B.;MANOHARAN MUTHIAH;BHAT BALKRISHEN;GRIFFEY RICHARD;SWAYZE ERIC E.;CROOKE STANLEY T.;RAJEEV KALLANTHOTTATHIL G. |
分类号 |
A61K38/00;C07H21/00;C12N9/22;C12N15/113;(IPC1-7):C12Q1/68;C07H21/02;A61K48/00 |
主分类号 |
A61K38/00 |
代理机构 |
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