发明名称 |
Compositions and methods for dendritic cell-based immunotherapy |
摘要 |
Disclosed are immunostimulatory fusion proteins and methods for generating protective DC-induced, T cell-mediated immune responses in vitro and in vivo. The immunostimulatory fusion proteins comprise a polypeptide antigen component and an immunostimulatory component derived from the intracellular domain of the HER-2 protein. Also disclosed are immunostimulatory compositions comprising dendritic cells pulsed with such an immunostimulatory fusion protein and the use of these compositions in methods for immunotherapy. |
申请公布号 |
NZ522066(A) |
申请公布日期 |
2004.08.27 |
申请号 |
NZ20010522066 |
申请日期 |
2001.03.30 |
申请人 |
DENDREON CORPORATION |
发明人 |
LAUS, REINER;VIDOVIC, DAMIR;GRADDIS, THOMAS |
分类号 |
C12N5/06;A61K35/12;A61K39/00;A61K39/385;A61P31/04;A61P31/10;A61P31/12;A61P33/00;A61P35/00;A61P37/04;C07K14/47;C07K14/535;C07K14/705;C07K14/71;C07K19/00;C12N9/16;C12N15/12;C12N15/27;C12N15/55;(IPC1-7):A61K39/385 |
主分类号 |
C12N5/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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