A STRUCTURED PEPTIDE SCAFFOLD FOR DISPLAYING TURN LIBRARIES ON PHAGE
摘要
The invention is directed to a model system for structure-activity analysis of peptide or protein molecules involved in important biological processes. Provided by the invention are combinatorial peptide libraries comprising disulfide-constrained cyclic peptides with sequences favorable for energy stabilized conformations. One aspect of the invention is directed to cyclic peptide scaffolds that present beta-hairpin structure in solution. Methods of selecting and using such peptide scaffolds are provided herein, which are useful for mimicking in vivo molecular interactions and designing therapeutic agents. Thus, the invention has profound utility for biological studies and drug development.
申请公布号
WO2004035735(A3)
申请公布日期
2004.08.26
申请号
WO2003US32450
申请日期
2003.10.14
申请人
GENENTECH, INC.;COCHRAN, ANDREA, G.;SKELTON, NICHOLAS, J.;STAROVASNIK, MELISSA, A.
发明人
COCHRAN, ANDREA, G.;SKELTON, NICHOLAS, J.;STAROVASNIK, MELISSA, A.