发明名称 |
Reversed mammalian protein-protein interaction trap |
摘要 |
The present invention relates to a recombinant receptor, comprising a ligand-binding domain and a signaling domain that comprises a heterologous bait polypeptide, which receptor is inactivated by binding of a prey polypeptide to the heterologous bait peptide, either in presence or absence of a ligand binding to the ligand-binding domain. The receptor is activated by addition of a compound that disrupts the bait-prey interaction. The present invention also relates to a method of screening compounds that disrupt compound-compound-binding using the recombinant receptor.
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申请公布号 |
US2004166538(A1) |
申请公布日期 |
2004.08.26 |
申请号 |
US20040751072 |
申请日期 |
2004.01.02 |
申请人 |
EYCKERMAN SVEN;TAVERNIER JAN;VANDEKERCKHOVE JOEL |
发明人 |
EYCKERMAN SVEN;TAVERNIER JAN;VANDEKERCKHOVE JOEL |
分类号 |
C07K14/47;C07K14/705;C12N15/10;(IPC1-7):C07K14/705;G01N33/53;G01N33/567 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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