| 摘要 |
Human beta-globin mutant polypeptides comprise the amino acid sequence of normal human beta-globin modified by (i) the substitution or deletion of Cys at amino acid positions 93 and 112, and (ii) the substitution of a Cys fore a non-Cys amino acid at one other position in the polypeptide, preferable Ser at amino acid position 9. Modified human hemoglobins containing this or other beta-globin mutations, and/or an alpha-globin mutation, are provided, as well as polymers of such modified hemoglobins. Nucleic acids, vectors, and transformed host cells for producing the beta-globin mutants are provided.
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