| 摘要 |
<p>In the present invention, there is described a novel process for preparing and purifying tramadol and tramadol-hydrochloride for pharmaceutical use thereof. When carrying out tramadol synthesis by employing Grignard reaction, there are also formed in addition to a desired (RR,SS)-tramadol, (RS,SR)-tramadol and 6- and/or 1-olefins as side products. When employing the invented process the (RS,SR)-tramadol is epimerized in the presence of acids and under low temperature to trans-tramadol. Solid tramadol is then isolated from a solution of a mixture of tramadol isomers in organic solvent, which solid tramadol can be optionally converted to tramadol-hydrochloride.</p> |
