| 摘要 |
Method for preparing a target substance in particulate form, by introducing into a particle formation vessel, through separate first and second fluid inlets respectively, (a) a solution or suspension of the target substance in a fluid vehicle (the "target solution/suspension") and (b) a compressed fluid anti-solvent for the substance, and allowing the anti-solvent to extract the vehicle from the target solution/suspension so as to form particles of the target substance, wherein the target solution/suspension enters the vessel downstream of the point of entry of the anti-solvent and at a point which lies on or close to the main axis of anti-solvent flow, and wherein the anti-solvent has a sub-sonic velocity as it enters the particle formation vessel. The anti-solvent is preferably a super critical or near super critical fluid.
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