| 摘要 |
Peroxisome Proliferator-Activated Receptor (PPAR) modulators (I), their optical and geometric isomers, and their salts are new. Peroxisome Proliferator-Activated Receptor (PPAR) modulators of formula (I), their optical and geometric isomers, and their salts are new. Ar1 = an optionally substituted phenyl, pyridine, pyrazine, pyridazine, pyrimidine; Z = a group meta to X in ring Ar1 and of formula -CH2-CO-Y-R1; Ar2 = an optionally substituted phenyl, pyridine, pyrazine, pyridazine, pyrimidine or ring of formula (k) - (n); R1 = H, 1-12C alkyl, aryl, heteroaryl, aralkyl, polyether, monohydroxy alkyl, or polyhydroxy alkyl; R2 = H, 1-12C alkyl, aryl, heteroaryl, aralkyl, polyether, monohydroxy alkyl, polyhydroxy alkyl, COR5 or CSR5; Y = O, S or NR4; R4 = H, 1-12C alkyl, aryl, heteroaryl, aralkyl, polyether, or together with R1 and the N atom of Y forms a heterocycle or heteroaryl group; R5 = 1-12C alkyl, aryl, heteroaryl, aralkyl, polyether, alkoxy, monohydroxy alkyl, or polyhydroxy alkyl, R6-N-R7 or O-R8; R6, R7 = H, 1-12C alkyl, aryl, heteroaryl, aralkyl, polyether, monohydroxy alkyl, or polyhydroxy alkyl, or taken together they form a heterocycle; R8 = H, 1-12C alkyl, aryl, heteroaryl, aralkyl, polyether, monohydroxy alkyl, or polyhydroxy alkyl; X = S, SO, SO2, Se, O, NR9, CO, HO-CR11, or R10-C-R11; R9 = H, COR12, 1-12C alkyl, polyether, aryl, or aralkyl; R10, R11 = H, 1-12C alkyl, aryl, heteroaryl, aralkyl, alkoxy, polyether, monohydroxy alkyl, polyhydroxy alkyl, or taken together form a ring that may be interrupted by hetero atoms; A = S, O, Se, or NR13; R12 = 1-12C alkyl; R13 = H, 1-12C alkyl, aryl, heteroaryl, aralkyl, or polyether.
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