| 摘要 |
The invention relates to the production and use of novel 14ss-alkyl-18-norsteroids, 8<,14ss-dialkyl-18-norsteroids, spiro[cyclopentano-perhydronaph-thalin]-3,1`-pentanes or hexanes in addition to 14ss-fluoro-15ss,17ss-dihydroxy-steroids, by reacting 17-hydroxy-14,15-epoxi-steroids with water-free acids or Lewis acids and followed by derivatisation. The resulting compounds can be used as intermediate products for or as medicaments in human and veterinary medicine, whereby the emphasis is on improving inflammatory processes, hormone replacement therapy and the use thereof as enzyme inhibitors in the treatment of tumours. |
