发明名称 |
NEUES GLYCOSAMINOGLYCAN UND DIESES ENTHALTENDES ARZNEIMITTEL |
摘要 |
There is provided a glycosaminoglycan having a backbone structure comprising a repetitive disaccharide bearing a uronic acid residue and a glucosamine residue, and having sulfate groups, wherein substantially no sulfate group bound to the hydroxyl group at the 6-position of the glucosamine residue in the backbone structure is detected as determined by a chemical disaccharide analysis method in which the glycosaminoglycan is decomposed with nitrous acid, reacted with para-nitrophenylhydrazine and analyzed by high performance liquid chromatography, and the molar % of a uronic acid residue having a sulfate group at the 2-position is not less than 45% relative to total uronic acid residues, which is calculated from a disaccharide composition obtained by an enzymatic disaccharide analysis method in which the glycosaminoglycan is digested with glycosaminoglycan-degrading enzymes and analyzed by high performance liquid chromatography. The glycosaminoglycan can be used as an active ingredient of phamaceuticals. <IMAGE> |
申请公布号 |
DE69918523(D1) |
申请公布日期 |
2004.08.12 |
申请号 |
DE1999618523 |
申请日期 |
1999.08.02 |
申请人 |
SEIKAGAKU CORP., TOKIO/TOKYO |
发明人 |
KARIYA, YUTAKA;TAKANO, RYO;KAMEI, KAEKO;HARA, SABURO;ONAYA, JUNICHI;HORI, YUSUKE |
分类号 |
C08B37/00;(IPC1-7):C08B37/10;A61K31/727 |
主分类号 |
C08B37/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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