发明名称 |
NON-STEROIDAL FXR AGONISTS |
摘要 |
ABSTRACT Potent non-steroidal farnesoid X receptor (FXR) agonists are N-aryl-N-arylmethyl amido and ureido compounds having the chemical structure represented by the following formula (I): INSERT FORMULA wherein E1 is (C1-C8)alkyl, cyclohexyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, phenyl, or NH(C1-C8)alkyl; L1 and L2 are both H, or together form a pi-bond; X1 is C(O), or CH2; Y1 is H, NHZ1, NH(Z2)Z3, or OZ4; aryl moiety A1 is selected from the group of radicals consisting of: INSERT FORMULA A2 and G1 - G11 are as defined in the specification; and T1 and T2 are each independently O, S, NH, or N(C1-C8)alkyl. The FXR agonists are useful as therapeutic agents for the treatment of diseases linked to cholesterol, bile acids, and their metabolism and homeostasis. |
申请公布号 |
WO2004046162(A3) |
申请公布日期 |
2004.08.12 |
申请号 |
WO2003US36195 |
申请日期 |
2003.11.14 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE;NICOLAOU, KYRIACOS, C.;ROECKER, ANTHONY, J.;HUGHES, ROBERT;PFEFFERKORN, JEFFREY, A. |
发明人 |
NICOLAOU, KYRIACOS, C.;ROECKER, ANTHONY, J.;HUGHES, ROBERT;PFEFFERKORN, JEFFREY, A. |
分类号 |
C07C233/54;C07C233/63;C07C275/42;C07C323/40;C07C323/41;C07C323/44;C07D277/28;C07D311/04;C07D311/58;C07D317/58;C07D333/20;C07D405/12;C07D409/12 |
主分类号 |
C07C233/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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