PREPARATION OF NEW PHARMACEUTICALLY SUITABLE SALT OF LOSARTAN AND FORMS THEREOF WITH NEW PURIFICATION AND ISOLATION METHODS
摘要
Pharmaceutically suitable crystalline and amorphous alkali and earth-alkali salts of 2-n-butyl-4-chloro-5-h idroxymethyl-1-[[2'-(1 H-tetrazole-5-yl)[1.1'-biphenyl]-4-yl]-1 Himidazole have been prepared and new manufacturing, purification and isolation procedure for said salts in high purity have been described. Stable pharmaceutical compositions containing new crystalline potassium salts of 2-n-butyl-4-chloro-5hidroxymethyl-1-[[2'-(1 H-tetrazole-5-yl)[1.1'-biphenyl]-4-yl]-1 H-imidazole have been prepared.
申请公布号
WO2004066997(A2)
申请公布日期
2004.08.12
申请号
WO2004SI00001
申请日期
2004.01.29
申请人
LEK PHARMACEUTICALS D.D.;ANTONCIC, LJUBOMIR;COPAR, ANTON;SVETE, PETER;HUSU-KOVACECIC, BREDA;HAM, ZORAN;MAROLT, BORIS
发明人
ANTONCIC, LJUBOMIR;COPAR, ANTON;SVETE, PETER;HUSU-KOVACECIC, BREDA;HAM, ZORAN;MAROLT, BORIS