| 发明名称 |
HUMAN MUTATOR GENE hMSH2 AND HEREDITARY NON POLYPOSIS COLORECTAL CANCER |
| 摘要 |
<p>The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error<+> (RER<+>) tumor cells.</p> |
| 申请公布号 |
EP0730648(B1) |
申请公布日期 |
2004.08.11 |
| 申请号 |
EP19950904201 |
申请日期 |
1994.12.02 |
| 申请人 |
THE JOHNS HOPKINS UNIVERSITY;DE LA CHAPELLE, ALBERT |
发明人 |
DE LA CHAPELLE, ALBERT;VOGELSTEIN, BERT;KINZLER, KENNETH, W. |
| 分类号 |
A01K67/027;A61K31/70;A61K31/711;A61K38/00;A61K38/22;A61K39/395;A61K45/00;A61K48/00;A61P35/00;A61P43/00;C07H21/04;C07K14/47;C07K14/82;C12N15/09;C12N15/12;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50;(IPC1-7):C12N15/12;A01K67/00 |
主分类号 |
A01K67/027 |
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