| 摘要 |
The invention relates to compounds of the formulawhereinR<1 >is lower alkyl, lower alkoxy, pyridinyl, pyrimidinyl, phenyl, -S-lower alkyl, -S(O)2-lower alkyl, -N(R)-(CH2)n-N(R)2, -O-(CH2)n-N(R)2, -N(R)2, or a cyclic tertiary amine of the groupwhich may contain one additional heteroatom, selected from N, O or S, and wherein this group may be connected with the pyrimidine ring via the linker -O(CH2)n-;R<2 >is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl;R<3>/R<3>' is, independently from each other, hydrogen or lower alkyl;R<4 >is independently from each other halogen, trifluoromethyl or lower alkoxy;R<5 >is hydrogen or lower alkyl;R is, independently from each other, hydrogen or lower alkyl;X is -C(O)N(R)- or -N(R)C(O)-;Y is -O-, -S-, -SO2-, - or -N(R)-;n is 1,2,3 or 4; andm is 0,1 or 2;or a pharmaceutically acceptable acid addition salt thereof. The compound of the invention has affintity to the NK1 receptor and is therefore suitable in the treatment of diseases related to this recepor. |
