METHOD OF USING PEPTIDYL ARGININE DEIMINASE TYPE IV

摘要

A method of evaluating the therapeutic effect of a remedy for rheumatoid arthritis and a method of estimating the risk for onset of rheumatoid arthritis by using peptidyl arginine deiminase type IV. Namely, it is intended to provide a method of evaluating the effect of a test substance as a remedy for rheumatoid arthritis by using its inhibitory effect on a peptidyl arginine deiminase type IV gene, an orthologous gene thereof or a protein encoded by the gene as an indication. It is also intended to provide a method of estimating the risk for onset of rheumatoid arthritis in a subject based on the expression amount of a mutant peptidyl arginine deiminase type IV protein comprising the amino acid sequence represented by SEQ ID NO:21 or its gene (SEQ ID NO:20) in a specimen which is provided by the subject.