CELL-SURFACE ESTROGEN RECEPTOR AND RELATED COMPOSITIONS AND METHODS

摘要

This invention provides an isolated mammalian cell-surface estrogen receptor characterized by (a) a non­stereospecific binding affinity for 17alpha-estradiol and 17beta-estradiol; (b) at least one epitope in common with the ligand-binding domain of ER-a; and (c) increased presence at caveolar or caveolar-like microdomains of cells on which the receptor is present. This invention further provides related methods for assaying compounds, activating the MAP kinase pathway of a cell, and delaying the onset of or treating disorders. Finally, this invention provides related articles and compositions of matter.