ORTHO- SUBSTITUTED BENZOYLGUANIDINES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A MEDICAMENT OR DIAGNOSTIC, AND MEDICAMENT COMPRISING THEM

摘要

BENZOYLGUANIDINES OF FORMULA I IWITH R(1) TO R(4) AS DEFINED IN THE SPECIFICATION, ARE SUITABLE AS ANTIARRHYTHMIC PHARMACEUTICALS HAVING A CARDIOPROTECTIVE COMPONENT FOR INFARCT PROPHYLAXIS AND INFARCT TREATMENT AS WELL AS FOR THE TREATMENT OF ANGINA PECTORIS. THEY INHIBIT, IN A PREVENTIVE MANNER, THE PATHOPHYSIOLOGICAL PROCESSES IN THE FORMATION OF ISCHEMICALLY INDUCED DAMAGE, IN PARTICULAR IN THE ELICITATION OF ISCHEMICALLY INDUCED CARDIAC ARRHYTHMIAS.