Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates for the preparation of the derivatives

摘要

A glucopyranosyloxybenzylbenzene derivative of formula (I), wherein R1 represents a hydrogen atom or a hydroxy (lower alkyl) group; and R2 represents a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a hydroxy (lower alkyl) group, a hydroxy (lower alkoxy) group, a hydroxy (lower alkylthio) group, a lower alkoxy-substituted (lower alkyl) group, a lower alkoxy-substituted (lower alkoxy) group or a lower alkoxy-substituted (lower alkylthio) group, or a pharmaceutically acceptable salt thereof. Also disclosed is a benzylphenol derivative of formula (II), wherein R11 represents a hydrogen atom or a protected hydroxy (lower alkyl) group; and R12 represents a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a protected hydroxy (lower alkyl) group, a protected hydroxyl (lower alkoxy) group, a protected hydroxy (lower alkylthio) group, a lower alkoxy-substituted (lower alkyl) group, a lower alkoxy-substituted (lower alkoxy) group or a lower alkoxy- substituted (lower alkylthio) group; with the proviso that R12 is not a methyl group, an ethyl group, an isopropyl group, a tert-butyl group or a methoxy group when R11 is a hydrogen atom, or a salt thereof.