| 摘要 |
The present invention provides novel macrolide compounds of the formulas wherein: R is hydrogen, substituted C1-C10 alkyl, unsubstituted C1-C10 alkyl, substituted C2-C10 alkenyl, unsubstituted C2-C10 alkenyl, substituted C2-C10 alkynyl, unsubstituted C2-C10 alkynyl, substituted aryl, unsubstituted aryl, substituted alkylaryl, unsubstituted alkylaryl, substituted alkenylaryl, unsubstituted alkenylaryl, substituted alkynylaryl, or unsubstituted alkynylaryl; R<0 >is hydroxyl or methoxy; R<1 >is selected from the group consisting of hydrogen, hydroxyl, halide, NH2, OR<9>, where R<9 >is substituted C1-C10 alkyl, unsubstituted C1-C10 alkyl, substituted C2-C10 alkenyl, unsubstituted C2-C10 alkenyl, substituted C2-C10 alkynyl, unsubstituted C2-C10 alkynyl, substituted aryl, unsubstituted aryl, substituted alkylaryl, unsubstituted alkylaryl, substituted alkenylaryl, unsubstituted alkenylaryl, substituted alkynylaryl, or unsubstituted alkynylaryl, and R<10 >and R<11 >are each independently hydrogen, substituted C1-C10 alkyl, unsubstituted C1-C10 alkyl, substituted C2-C10 alkenyl, unsubstituted C2-C10 alkenyl, substituted C2-C10 alkynyl, unsubstituted C2-C10 alkynyl, substituted aryl, unsubstituted aryl, substituted alkylaryl, unsubstituted alkylaryl, substituted alkenylaryl, unsubstituted alkenylaryl, substituted alkynylaryl, or unsubstituted alkynylaryl; R<2 >and R<3 >are each independently selected from the group consisting of hydrogen, substituted C1-C10 alkyl, unsubstituted C1-C10 alkyl, substituted C2-C10 alkenyl, unsubstituted C2-C10 alkenyl, substituted C2</hi
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