beta-CATENIN OLIGONUCLEOTIDE MICHROCHIP AND METHOD FOR DETECTING beta-CATENIN MUTATIONS EMPLOYING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a β-catenin oligomucleotide microchip and to provide a method for detecting β-catenin mutations employing the same.

SOLUTION: The invention relates to β-catenin oligomucleotide microchip for detecting a variety of mutations at the mutational hot spots of β-catenin gene, and the manufacturing process thereof and the method for detecting mutations of the β-catenin gene, the oligonucleotides are designed to detect various missense mutations and for detecting in-frame deletions at codons of the mutational hot spots of β-catenin gene. The β-catenin oligonucleotide microchip is useful for detecting mutations of the β-catenin gene and for studying the signal transduction mechanism and tumorigenesis related to β-catein gene.

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