| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a gene-modified animal in which the expression of a LOX-1 gene pair is inactivated, capable of being used for elucidating physiological activities of the LOX-1 in an individual body level and enabling the utilization of the same for a research on a therapeutic agent, etc., of diseases including arteriosclelosis, etc., associated with the gene. <P>SOLUTION: This LOX-1 defective mouse is produced by a gene-targeting method. By an analysis using the produced LOX-1 gene defective mouse, it becomes clear that a LOX-1 antagonist is useful for improving a morbid state caused by the lowering of endothelial function. Also, it becomes clear that the LOX-1 is associated with an infection with a protozoan. Thus, the LOX-1 gene defective animal is a useful model for elucidating a new function of the LOX-1. The knock out mouse of the function of the LOX-1 gene becomes a useful model mouse for exploring the unknown role of the LOX-1 gene in the onset and development of the arteriosclerosis, etc. <P>COPYRIGHT: (C)2004,JPO&NCIPI</p> |
