发明名称 |
Chimeric oligomeric compounds and their use in gene modulation |
摘要 |
Oligomer compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capble of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes at least one nucleotide comprising a chimeric organic composition. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide comprising a chimeric organic composition. |
申请公布号 |
US2004147023(A1) |
申请公布日期 |
2004.07.29 |
申请号 |
US20030701265 |
申请日期 |
2003.11.04 |
申请人 |
BAKER BRENDA F.;ELDRUP ANNE B.;MANOHARAN MUTHIAH;BHAT BALKRISHEN;GRIFFEY RICHARD H.;SWAYZE ERIC E.;CROOKE STANLEY T. |
发明人 |
BAKER BRENDA F.;ELDRUP ANNE B.;MANOHARAN MUTHIAH;BHAT BALKRISHEN;GRIFFEY RICHARD H.;SWAYZE ERIC E.;CROOKE STANLEY T. |
分类号 |
A61K48/00;C07H21/02;C07H21/04;(IPC1-7):A61K48/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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