发明名称 |
Altered antibodies and their preparation |
摘要 |
An altered antibody chain is produced in which the CDR's of the variable domain of the chain are derived from a first mammalian species. The framework-encoding regions of DNA encoding the variable domain of the first species are mutated so that the mutated framework-encoding regions encode a framework derived from a second different mammalian species. The or each constant domain of the antibody chain, if present, are also derived from the second mammalian species.
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申请公布号 |
US6767996(B1) |
申请公布日期 |
2004.07.27 |
申请号 |
US19930030175 |
申请日期 |
1993.05.17 |
申请人 |
GLAXO WELLCOME INC. |
发明人 |
GORMAN SCOTT DAVID;CLARK MICHAEL RONALD;COBBOLD STEPHEN PAUL;WALDMANN HERMAN |
分类号 |
A61K39/395;A61K38/00;A61P37/00;C07K16/28;C12N15/13;C12P21/08;(IPC1-7):C07K16/00;C12P21/04;C07H21/04 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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