发明名称 |
Immunoglobulin construct containing anti-mucin variable domain sequences for eliciting an anti-idiotype anti-tumor response |
摘要 |
The present invention provides a variant of an immunoglobulin variable domain including (A) at least one CDR region and (B) framework regions flanking the CDR region, wherein the variant also contains (a) a CDR region having added or substituted therein at least on binding sequence and (b) the flanking framework regions, wherein the binding sequence is heterelogous to the CDR and is an antigenic sequence from a MUC-1 binding sequence.
|
申请公布号 |
US2004143101(A1) |
申请公布日期 |
2004.07.22 |
申请号 |
US20030469125 |
申请日期 |
2003.08.25 |
申请人 |
SOLTIS DANIEL A.;BURCH RONALD M;SHUKLA RAJIV |
发明人 |
SOLTIS DANIEL A.;BURCH RONALD M;SHUKLA RAJIV |
分类号 |
A61K39/00;A61P35/00;C07K14/705;C07K16/00;C07K16/18;C07K16/28;C12N15/13;(IPC1-7):C07K16/30 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|