A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug t o its toxic form when compared against the E. coli enzyme.
申请公布号
CA2506329(A1)
申请公布日期
2004.07.22
申请号
CA20032506329
申请日期
2003.12.23
申请人
ONYX PHARMACEUTICALS, INC.
发明人
SHEN, JERRY YUQIAO;DELANEY, AMY M.;LAQUERRE, SYLVIE;OMER, CHARLES A.
