发明名称 |
Proteins and polypeptides from coagulase-negative staphylococci |
摘要 |
Proteins and polypeptides from coagulase-negative staphylococcal bacteria such as S. epidermidis, including proteins designated SdrF, SdrG and SdrH, and their effective fragments such as their respective A domains, are provided which are useful in the prevention and treatment of infection caused by coagulase-negative staphylococcal bacteria such as S. epidermidis. The SdrF, SdrG and SdrH proteins are cell-wall associated proteins that specifically bind host proteins and which each have a highly conserved motif of which the consensus sequence is TYTFTDYVD (SEQ ID NO: 16). The proteins and polypetides may be useful in generating antibodies for the diagnosis and treatment of coagulase-negative staphylococcal infections.
|
申请公布号 |
US2004142348(A1) |
申请公布日期 |
2004.07.22 |
申请号 |
US20030689082 |
申请日期 |
2003.10.21 |
申请人 |
FOSTER TIMOTHY J.;MCCREA KIRK;HOOK MAGNUS A.O.;DAVIS STACEY;NIEIDHIN DEIRDRE;HARTFORD ORLA |
发明人 |
FOSTER TIMOTHY J.;MCCREA KIRK;HOOK MAGNUS A.O.;DAVIS STACEY;NIEIDHIN DEIRDRE;HARTFORD ORLA |
分类号 |
G01N33/50;A61K38/00;A61K39/00;A61K39/085;A61K39/395;A61K48/00;A61L27/00;A61L29/00;A61L31/00;A61P9/00;A61P17/02;A61P19/00;A61P31/04;C07K14/31;C07K16/12;C12N15/09;C12Q1/02;C12R1/44;C12R1/45;G01N33/15;G01N33/569;(IPC1-7):C12Q1/68;C07H21/04 |
主分类号 |
G01N33/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|