发明名称 |
Metalloprotease activation of myostatin, and methods of modulating myostatin activity |
摘要 |
It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of modulating muscle growth in an organism by increasing or decreasing metalloprotease mediated cleavage of a myostatin pro peptide.
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申请公布号 |
US2004138118(A1) |
申请公布日期 |
2004.07.15 |
申请号 |
US20030662438 |
申请日期 |
2003.09.16 |
申请人 |
WOLFMAN NEIL;TOMKINSON KATHY |
发明人 |
WOLFMAN NEIL;TOMKINSON KATHY |
分类号 |
A61K38/00;A61K38/16;A61K38/18;C07K14/475;C12N9/64;(IPC1-7):A61K38/16 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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