NOVEL ETHYLENEDIAMINE DERIVATIVES

摘要

A compound represented by the following general formula (1): Q<1>-Q<2>-T<0>-N(R<1>)-Q<3>-N(R<2>)-T<1>-Q<4> (1) wherein R<1> and R<2> represent each hydrogen, etc.; Q<1> represents optionally substituted and saturated or unsaturated 5- to 6-membered cyclic hydrocarbyl, etc.; Q<2> represents a single bond, etc.; Q<3> represents a group -C(R<3a>)(R<4a>)-{C(R<3b>)(R<4b>)}m<1>-{C(R<3c>)(R<4c>)}m<2>-{C(R<3d>)(R<4d>)}m<3>-{C(R<3e>)(R<4e>)}m<4>-C(R<3f>)(R<4f>)- (wherein R<3a> to R<4e> represent each hydrogen, etc.); T<0> represents carbonyl, etc.; and T<1> represents -COCONR-, etc.; its salt, solvates thereof or N-oxides of the same. These compounds are useful as preventives and/or remedies for cerebral infarction, cerebral embolism, myocardial infarction, angina, pulmonary infarction, pulmonary embolism, Burger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombosis after artificial valve/joint replacement, thrombosis and reocclusion after reconstructing blood circulation, systemic inflammatory response syndrome (SIRS), multiorgan dysfunction syndrome (MODS), thrombosis in extracorporeal circulation and blood coagulation in blood collection.