发明名称 |
Enhanced relaxivity monomeric and multimeric compounds |
摘要 |
Metal chelates capable of exhibiting an immobilized relativity between about 60 and 200 mM<-1>s<-1>/metal atom are useful as magnetic resonance imaging agents. Additionally, a compound which is useful as a metal-chelating ligand has the following formula: wherein Q is a 4- to an 8-membered carbocyclic ring which may be fully or partially saturated; t is an integer from 2 to 16; each R group is independently hydrogen, -OH, -CH2-A, -OCH2CH(OH)CH2-A or a functional group capable of forming a conjugate with a biomolecule, provided that at least two of the R groups are selected from -CH2-A or -OCH2CH(OH)CH2-A; and A is a moiety capable of chelating a metal atom.
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申请公布号 |
US2004131551(A1) |
申请公布日期 |
2004.07.08 |
申请号 |
US20030741872 |
申请日期 |
2003.12.19 |
申请人 |
RANGANATHAN RAMACHANDRAN S.;PILLAI RADHAKRISHNA;RATSEP PETER C.;SHUKLA RAJESH;TWEEDLE MICHAEL F.;ZHANG XUN |
发明人 |
RANGANATHAN RAMACHANDRAN S.;PILLAI RADHAKRISHNA;RATSEP PETER C.;SHUKLA RAJESH;TWEEDLE MICHAEL F.;ZHANG XUN |
分类号 |
C07D317/46;A61K49/06;C07D257/02;C07D405/14;C07D493/10;C07F5/00;C07F9/6524;C09K3/00;(IPC1-7):A61K49/00 |
主分类号 |
C07D317/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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