| 摘要 |
The present invention provides compounds having formula (I): wherein R', R<0>, R<1>, X<1>, R<2>, R<3>, R<3'>, X<2>, X<3 >and R<4 >are as defined herein, and pharmaceutical compositions thereof. The present invention also provides methods of inhibiting proteases, more specifically aspartyl proteases. In certain embodiments, compounds inhibit BACE (beta-site APP-cleaving enzyme), and thus are useful in the treatment or prevention of a disease characterized by beta-amyloid deposits in the brain (including, but not limited to, Alzheimer's Disease). The present invention also provides methods for preparing compounds of the invention.
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