摘要 |
This invention describes novel pyrazole compounds of formula IV: wherein Z<1 >or Z<2 >is nitrogen, Q is -S-, -O-, -N(R<4>)-, -C(R<6>')2-, 1,2-cyclopropanediyl, 1,2-cyclobutanediyl, or 1,3-cyclobutanediyl, and R<1 >is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R<x >and R<y >are independently selected from T-R<3 >or L-Z-R<3>, or R<x >and R<y >are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-7-membered ring having 0-3 heteroatoms; and R<2 >and R<2'> are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
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